New Publication

Poster: Designing PAMPA Permeable Macrocycles: Exploring Promising Directions in Early Drug Discovery Research

Anna Rzepiela, Mark Parisi, Roman Kombarov, Ramon Moreno, Victor Tatarsky
April 23-27, 2017 - 12th Annual Drug Discovery Chemistry, San Diego, CA USA
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New Products & Updates

Product Name: Format/SizeDescriptionsDownload
Signature Libraries4800 compounds
Release: 2015-2016
Update: 2016-10
ASINEX's cutting edge chemistry combined with in silico and in vitro screening validation. Favorable results are packaged in an easy to use, one plate format (80 compounds). For more information, please download >>>

List of all "Signature Libraries" pleaseclick here.
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Asinex Building Blocks
For DNA-encoded libraries
1738 Compounds
Update: 2017-05
DNA-encode libraries (DEL) are a valuable discovery tool for the identification of promising hits against multiple challenging targets. Compounds in DNA encoded libraries are synthesized form chemical building blocks exploiting DNA-compatible combinatorial chemistry. Strategic selection of building blocks helps generate excellent chemical diversity in library generation. Specific polyfunctional monomers provide an additional advantage as they can be flexibly applied to all established DEL enabling strategies: templated synthesis, combinatorial “split-and-pool’’ etc.
At ASINEX we have created several hundred bi and tri-functional low MW monomers providing flexibility in DNA tagging chemistry and allowing further opportunity for molecule growth and linking.
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Macrocyclic Glycomimetics2048 compounds
For cherry-picking
Update: 2017-05
Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites. For more information, please download >>>sdf-icon pdf-icon
PPI Pre-Plated Set8637 compounds
Pre-Plated Set
Amount: 0.01-2.0 mg
Update: 2017-03
ASINEX has been working on the design and synthesis of protein-protein interaction (PPI) libraries since 2008. The latest generation of ASINEX PPI Library comprises molecules of various sizes, frameworks, and shapes ranging from fragment-like entities to macrocyclic derivatives designed as secondary structure mimetics or as epitope mimetics. For more information, please download >>>sdf-icon pdf-icon
Kinase Pre-Plated Set6502 compounds
Pre-Plated Set
Amount: 0.01-2.0 mg
Update: 2017-05
ASINEX facilitates the discovery of novel kinase inhibitors by providing access to our advanced collection of small molecules, fragments and macrocycles. The efficacy of our compounds has been validated through in silico modeling and in vitro on-target and phenotypic profiling. This is paralleled with 20+ years of medicinal chemistry expertise, delivering designs with outstanding ADMET and PK properties, optimizing chances in hit to candidate development. For more information, please download >>>
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Glycomimetics Pre-Plated Set2439 compounds
Pre-Plated Set
Amount: 0.01-2.0 mg
Update: 2017-03
ASINEX has overcome these obstacles by creating a glycomimetic library that ensures the bioactive function of carbohydrates while addressing the drawbacks of carbohydrates, such as their low activity and poor drug-like properties. For more information, please download >>>sdf-icon pdf-icon

 

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