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ASINEX's Glycomimetic Library
High pharmacophore density of sugar-like compounds
Carbohydrates and carbohydrate-like molecules represent a particularly intriguing part of chemical space, due to their pivotal role in regulating many biological processes and providing valuable chemical starting points for the design of novel small-molecule drugs [1]. Cyclic amino alcohols and cyclic glycols are the common structural features of carbohydrates and other natural products. They constitute very important protein recognition pharmacophores exploited in industry for the design of new drugs (e.g. anti-infective agents) and as "chemical chaperones" [2]. However due to the presence of several stereogenic centers, high polarity and high saturation, the synthetic feasibility of such compounds represent additional hurdles for medicinal chemists. It is not surprising that such highly valuable chemotypes are under-represented in commercial compound collections.
In order to address this challenge ASINEX has designed a special library of 2700 novel carbohydrate-like compounds enriched with poly OH(NH) pharmacophores. Our synthetic expertise enabled us to produce compounds as single diastereoisomers, with the structures confirmed by both 2D NMR and X-ray crystallography. All final compounds demonstrate exceptionally good solubility in aqueous media and are chemically stable which makes them ideal for screening in multiple applications:
- Protein-protein interactions
- Proteases
- Antiviral/antibacterial targets
Additionally, 700 compounds with MW < 250 represent a very valuable source of unique fragment-like molecules which have been specifically refined and tested for solubility in aqueous media. These compounds are available for purchasing in larger quantities (up to 100 mg).
Library specifics
Measured Solubility: 100% of compounds are soluble in DMSO at 10 uM, and in PBS at 100 µM
Quality: min.purity of 90%, avg. of 95% (100% LC-MS, 15% NMR), stored as dry powder
ASINEX's Glycomimetic Library is only available upon request, please contact us at:
Tel.: +7 (495) 780 34 15, +7 (495) 780 34 10
E-mail : or
1. Beat Ernst, John L. Magnani. From carbohydrate leads to glycomimetic drugs, Nature Reviews Drug Discovery 8, August 2009, pp 661-677.
2. Zhanqian Yu, et al. Isofagomine- and 2,5-Anhydro-2,5-imino-d-glucitol-Based Glucocerebrosidase Pharmacological Chaperones for Gaucher Disease Intervention, J. Med. Chem., 2007, 50 (1), pp 94-100.
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