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Minimalist Libraries

 

ASINEX's Minimalist Libraries 2011
17000 compounds / 125 scaffolds

High Skeletal Diversity Inspired by Nature

ASINEX continues to develop a compendium of natural product-like libraries by incorporating structural features of pharmacologically relevant natural products into the scaffold skeletons of synthetic compounds. In order to identify privileged pharmacophores, ring systems and linkers, we have carried out a statistical analysis of natural product alkaloids, marketed drugs and commercial libraries. It was found that saturated linked, fused, spiro and bridged ring systems, with a tendency towards chirality, are highly privileged among natural products and marketed drugs, but at the same time are poorly represented in commercial libraries.

Minimalist Library

This data is consistent with the synthetic accessibility of such structural elements and clearly indicates areas of high chemical complexity where traditional methods of combinatorial chemistry are barely applicable. In order to address these challenging areas ASINEX's chemists have focused their attention on more sophisticated stereo-controlled reactions and biomimetic transformations such as

  • Epoxide tandem transformations
  • Olefin transformations
  • Asymmetric rearrangements

The applied synthetic strategy provided the compounds with:

  • Exceptionally high shape and stereochemical complexity [1]
  • Increased number of minimalist pharmacophoric elements [2]
  • A high number of O-atoms per molecule

These are characteristic features differentiating natural products from "common" synthetic molecules.

The skeletal diversity is represented by fused, spiro, bridged and macrocylic (rings with > 8 atoms) frameworks. In many cases the position of heteroatoms and functional groups within the framework emulates the corresponding molecular pattern of marine toxins, carbohydrates and alkaloids.

Unlike typical DOS-derived molecules, Biomimetic compounds do not contain undesirable functionalities and are optimized in terms of physico-chemical parameters. Moreover, the Biomimetic library is supported by a special collection of advanced intermediates and building blocks available in multi-gram quantities. The final compounds with MW<275 Da represent a very valuable source of unique, three-dimensional, fragment-like molecules which have been specifically refined and tested for solubility in aqueous media.

The Biomimetic Library provides a very rich source of original peptidomimetic scaffolds and is ideal for probing challenging target classes including:

  • Protein-protein interactions
  • Proteases
  • Ion Channels
  • Antibacterial / antiviral targets

Library specifics
Quality: min.purity of 90%, avg. of 95% (LC-MS, NMR), stored as dry powder

For more information please contact ASINEX at:
Tel.: +7 (495) 780 34 15, +7 (495) 780 34 10
E-mail : LSadovenko@asinex.com or Busdev@asinex.com


1. Paul A. Clemons, et al. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles PNAS , November 2, 2010 , vol. 107 , no. 44, 18787-187922.
2. Gilbert M Rishton, Molecular diversity in context of leadlikeness: compound properties that enable effective biochemical screening, Curr Opin Chem Biol 2008, 12: 1-12.

 
 
 
 
 
 
 
 
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