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| Home > BioDesign > BioDesign F2LTM |
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| Oxy Set |
ASINEX's Oxy set is a part of our Fragment to Lead (F2L) research tool series, which consists of molecules that have a molecular weight in the range of 250-350 Da. This makes the library ideal for generating high ligand efficiency hits as well as for the progression of fragments into leads.
Structures of natural products (NPs) have always been a valuable source of inspiration for the design of novel structurally complex small molecules. The skeletons of natural products are often formed by saturated, fused rigid, oxygen-enriched ring systems [1]. Asinex Oxy Set is a collection of 2000 small molecules based on 25 unprecedented oxygen-enriched saturated scaffolds. Such molecules effectively mimic NP properties and may prove to be especially useful for several areas of drug discovery: for example anti-bacterial, anti-tuberculosis and anti-cancer agents [2. 3]. Furthermore, they have intrinsically good ADMET values and excellent solubility. |
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Oxy Set
MW <= 350; Mean MW: 325
ClogP <= 3
H-Bond Acceptors <= 7
H-Bond Donors <= 3
TPSA <= 100
Solubility in PBS > 10 µg/mL
Solubility DMSO > 100 mM
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Examples of ASINEX Oxy Set compounds
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Quantity: 1mg - 100mg
Purity: 90% min.
Delivery: 1-2 weeks
For more information and to see the complete set of scaffolds and molecules please contact ASINEX at:
Tel.: +7 495 780 3417
Email: Busdev@asinex.com
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| 1. |
Petersen F, Amstutz R (2008) Natural compounds as drugs, volume 66, Birkhauser Verlag, Switzerland, pp 217-235 |
| 2. |
Rosemarie O'Shea and Heinz E. Moser, Physicochemical Properities of Antibacterial Compounds: Implications for Drug DiscoveryWolfgang H. B. Sauer and Matthias K. Schwarz Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity, J. Med. Chem., 2008, 51 (10), pp 987-10037 |
| 3. |
Gordon M. Cragg, Paul G. Grothaus, and David J. Newman, Impact of Natural Products on Developing New Anti-Cancer Agents, Chem. Rev. 3012 2009, 109, 3012-3043 |
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