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| Home > BioDesign > BioDesign F2LTM |
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| Shape Enhancer Set |
ASINEX's Shape Enhancer set is a part of our Fragment to Lead (F2L) research tool series, which consists of molecules that have a molecular weight in the range of 250-350 Da. This makes the library ideal for generating high ligand efficiency hits as well as for the progression of fragments into leads.
Asinex Shape Enhancer is a set of 500 unprecedented highly diverse molecules with a specific 3D-geometry which enables the coverage of under-explored areas of the shape universe [1]. ASINEX's Shape Enhancer set is orientated towards the empty 'Eastern' part of chemical space. 3-dimensional molecules are especially suitable for hit generation against difficult targets when sphere-shaped ligands are required for effective interaction. |
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Envelope-like representation of molecular shapes of SCD compounds (MW 150-350) [1]
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Envelope-like representation of molecular shapes of ASINEX Shape Enhancer
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Shape Enhancer
MW <= 350; Mean MW: 325
ClogP <= 3
H-Bond Acceptors <= 7
H-Bond Donors <= 3
TPSA <= 100
Solubility in PBS > 10 µg/mL
Solubility DMSO > 100 mM
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Quantity: 1mg - 100mg
Purity: 90% min.
Delivery: 1-2 weeks from Moscow
For more information and to see the complete set of scaffolds and molecules please contact ASINEX at:
Tel.: +7 495 780 3417
Email: Busdev@asinex.com
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| 1. |
Wolfgang H. B. Sauer and Matthias K. Schwarz Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity, J. Chem. Inf. Comput. Sci., 2003, 43 (3), pp 987-10037 |
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