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SpiroCore Array

ASINEX's SpiroCore Array is a part of our Fragment to Lead (F2L) research tool series, which consists of molecules that have a molecular weight in the range of 250-350 Da. This makes the library ideal for generating high ligand efficiency hits as well as for the progression of fragments into leads.

Asinex SpiroCore Array is a set of 2000 molecules based on 40 unprecedented scaffolds containing a 'spiro' framework as a central core. The spiro motif is a prominent element which can be found in various interesting biologically-active molecules and natural products [1]. The unique 3D architecture of a spiro carbon in combination with appropriate terminal decoration enables the SpiroCore molecules to demonstrate a diverse, yet drug-like molecular shape distribution [2] (Fig.1). The resulting set of lead-like, chemically tractable molecules is useful for probing a great variety of biological targets, especially where existing collections have failed to generate hits. Besides being the favourite design tools for creative medicinal chemists, spiro compounds also have a high incidence of showing activity in a large majority of screens.

SpiroCore
MW <= 350; Mean MW: 325
ClogP <= 3
H-Bond Acceptors <= 7
H-Bond Donors <= 3
TPSA <= 100
Solubility in PBS > 10 µg/mL
Solubility DMSO > 100 mM

Examples of ASINEX SpiroCore compounds:

Quantity: 1mg - 100mg
Purity: 90% min.
Delivery: 1-2 weeks

For more information and to see the complete set of scaffolds and molecules please contact ASINEX at:
Tel.: +7 495 780 3417
Email: Busdev@asinex.com

1.	Ian D. Jenkins et al. Synthesis of Four Novel Natural Product Inspired Scaffolds for Drug Discovery, J. Org. Chem., 2009, 74 (3), pp 1304-1313
2.	Wolfgang H. B. Sauer and Matthias K. Schwarz Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity, J. Chem. Inf. Comput. Sci., 2003, 43 (3), pp 987-1003