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StereoCore Array

ASINEX's StereoCore Array a part of our Fragment to Lead (F2L) research tool series, which consists of molecules that have a molecular weight in the range of 250-350 Da. This makes the library ideal for generating high ligand efficiency hits as well as for the progression of fragments into leads.

Asinex StereoCore Array is a set of 2500 molecules based on 40 unprecedented scaffolds containing a saturated aza-bicyclic system as a central core. These motifs have always proved challenging for synthetic chemists but abandoned due to the stereo-synthetic shortcomings. Even though each StereoCore scaffold contains at least two chiral centers the stereochemistry of each molecule has been unambiguously defined by an appropriate synthetic methodology. The resulting molecules closely mimic some biologically relevant natural products [1] such as alkaloids and endogenic peptides [2] and therefore may effectively modulate challenging biological processes: protein-protein interactions, proteases activity, antibacterial / antiviral activity.

A comparison of the number of chiral centers between known drugs, natural products, and public-available compounds [1]

Examples of ASINEX StereoCore compounds

Quantity: 1mg - 100mg
Purity: 90% min.
Delivery: 1-2 weeks

For more information and to see the complete set of scaffolds and molecules please contact ASINEX at:
Tel.: +7 495 780 3417
Email: Busdev@asinex.com

1.	Feher M, JM Schmidt (2003) Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry.J. chem.. Inf. Comput. Sci. 2003 43, 218-277
2.	H. Sun et al J. Design, Synthesis, and Evaluation of a Potent, Cell-Permeable, Conformationally Constrained Second Mitochondria Derived Activator of Caspase (Smac) Mimetic J. M ed. Chem., 2006, 49 (26), pp 7916-7920