Antiviral

Product Name: Format/SizeDescriptionsDownload
Antiviral Library8722 compounds
For cherry-picking
Update: 2016-11
The design and discovery of novel chemical entities with profound antiviral activity and improved safety profiles requires an access to high quality screening compounds that could deliver a meaningful starting point for further development. ASINEX has developed several libraries of small molecules and macrocycles that could facilitate the discovery of novel valuable lead compounds using either target-directed or target-unbiased screening approaches. Specific designs include a-helix mimetics, glycomimetic, diverse synthetic macrocyles, and tri/tetra-substituted scaffolds. For more information, please download >>>sdf-icon pdf-icon
SL#061
Antimalarial Agents-1
80 compounds
Pre-Plated Set
Release: 2017
Structures (SDF) is now available >>>sdf-icon
SL#069
Interferon (IFN) inducers chemical probes
80 compounds
Pre-Plated Set
Release: 2017
Structures (SDF) is now available >>>sdf-icon
SL#070
HIV TAR RNA small molecule binders
80 compounds
Pre-Plated Set
Release: 2017
Structures (SDF) is now available >>>sdf-icon

 

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Product Name: Format/SizeDescriptionsDownload
α-Helix Mimetics8882 compounds
For cherry-picking
Update: 2016-11
It is well known that α-helix mimetics are biologically active in a number of therapeutically significant protein-protein interactions (PPIs). The file contains all available α-Helix mimetics selected from ourSignature & BioDesign Libraries.For more information, please download >>>sdf-icon pdf-icon
SL#030
α-Helix mimetics
80 compounds
Pre-Plated Set
Release: 2016
Using extensive computer modeling supported by in vitro experiments, ASINEX has created a number of structurally sophisticated, novel molecules based on the tetrahydropyrane scaffold that work as effective epitope mimetics of more than 20 various helical protein interfaces (e.g. ATG3/ATG12, Bcl-2, Aquaporin 2, Protein S100-A9). For more information, please download >>>sdf-icon pdf-icon
SL#032
Macrocyclic BH3 mimetics
80 compounds
Pre-Plated Set
Release: 2016
Extensive in vitro screening of the Asinex Macrocyclic collection has revealed a series of molecules showing a μM range of activity against anti-apototic proteins Bcl-2 and Mcl-1. In silico modeling studies suggest that some active macrocycles can adopt a-helix-mimetic conformations that effectively mimic the BH3-epitope of pro-apoptotic peptides (e.g. Bak, Bax). For more information, please download >>>sdf-icon pdf-icon
Product Name: Format/SizeDescriptionsDownload
Nucleoside Mimetics3866 compounds
For cherry-picking
Update: 2016-11
ASINEX has developed a number of stereo- and enantio-selective methods for the synthesis of nucleoside-like core intermediates (e. g. mimics of adenosine). These unique intermediates have been extensively decorated by various long chain amines, acids and amino acids. For more information, please download >>>sdf-icon pdf-icon
SL#010, 052
Purine-based Nucleosides
80 compounds x 2
Pre-Plated Set
Release: 2016
Compounds targeting the SAM/SAH site of these enzymes offer great potential, yet very few such molecules are currently described in literature or commercially available in compound collections. To address this market need, ASINEX has used a modular approach to synthesize a library of purine-based nucleosides. The main challenge was to develop stereo- and enantio-selective methods for the synthesis of nucleotide-like cores which both mimic adenosine and are metabolically stable. For more information, please download >>>sdf-icon pdf-icon
Product Name: Format/SizeDescriptionsDownload
Glycomimetics7283 compounds
For cherry-picking
Update: 2016-11
The file contains all available Glycomimetics selected from ourSignature & BioDesign Libraries.For more information, please download >>>sdf-icon pdf-icon
Macrocyclic Glycomimetics2048 compounds
For cherry-picking
Update: 2017-05
Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites. For more information, please download >>>sdf-icon pdf-icon
SL#006, 007, 017, 028
Glycomimetics
80 compounds x 4
Pre-Plated Set
Release: 2016
ASINEX has overcome these obstacles by creating a glycomimetic library that ensures the bioactive function of carbohydrates while addressing the drawbacks of carbohydrates, such as their low activity and poor drug-like properties. For more information, please download >>>sdf-icon pdf-icon
SL#038
Glycomimetics/Immunology
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has employed unique synthetic methods to create a library of synthetic glycomimetics where the carbohydrate ring is replaced by pyrrolidine. For more information, please download >>>sdf-icon pdf-icon
SL#008, 016, 036, 039
Macrocyclic Glycomimetics
80 compounds x 4
Pre-Plated Set
Release: 2016
Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites. For more information, please download >>>sdf-icon pdf-icon
SL#055, 056
Arabinose Glycomimetics
80 compounds x 2
Pre-Plated Set
Release: 2016
ASINEX has created a library of glycomimetic derivatives based on D-(-)-Arabinose. The presence of amine in the resulting scaffold allows a broad variation of substituents while retaining the stereochemical configuration of the cyclic amino polyol scaffold. For more information, please download >>>sdf-icon pdf-icon
SL#057, 058
Carbocyclic Glycomimetics
80 compounds x 2
Pre-Plated Set
Release: 2016
ASINEX has developed an efficient synthetic strategy to create five and six-membered carbocylic glycomimetic scaffolds with strategically orientated peripheral substituents. For more information, please download >>>sdf-icon pdf-icon

Please click here for List of all Signature Libraries.

 

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