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| Home > BioDesign > Bio Building Blocks, BioFragments |
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| Bio Building Blocks |
Bio Building Blocks are the core elements of ASINEX’s new BioDesign range of compound libraries. These molecules are the foundation upon which the whole range of libraries have been created, 1300 of these highly novel building blocks are now available for acquisition.
Rare secondary amines and carboxcylic acids make up the majority of this library. ASINEX Bio Building Blocks are alkaloid-like and are composed of fragments similar to ergoline, quinine, nicotine, anabasine, cytosine, epibatadine, acromellic acid etc.
These novel, carefully designed starting materials can be used as ingredients for library generation or for optimization of lead compounds.The high novelty of these building blocks is certain to lead to a clear IP position. A separate subset of precursors is also available.
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| BioFragments |
BioFragments comprises of 1800 especially small compounds ideal for fragment-based screening. These compounds are in essence bare templates that have been carefully decorated with ‘small caps’ - very low molecular weight peripheral building blocks. All of our fragments are unprecedented, we believe novelty is often underestimated, so we aim to ensure good IP at an early stage.
This product has a very attractive ratio of ligand efficiency due to the low number of heavy atoms which is essential for fragment- based screening (less than 18). Most compounds have 2-3 ‘spider-like’ synthetic handles and a large number of analogues which are readily available from our stock
Good solubility is especially important for fragment based screening and our compounds are tested in house for solubility (DMSO: > 10 mM, PBS: > 100 µM).
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| Bio Building Blocks |
BioFragments |
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14,100 BioDesign Fragment-Based Compounds |
| Sub-library |
Size |
MW |
cLogP |
Heavy Atoms |
HBA |
HBD |
TPSA |
| Bio Building Blocks |
1300 |
≤ 220 |
≤ 2.5 |
- |
≤ 7 |
≤ 3 |
≤ 100 |
| BioFragments |
1,800 |
120-250 |
≤ 2.5 |
9-18 |
≤ 6 |
≤ 3 |
≤ 110 |
| BioDesign F2LTM |
12,000 |
250-350 |
≤ 3 |
19-22 |
≤ 6 |
≤ 3 |
≤ 115 |
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| BioDesign F2LTM |
| ASINEX's Fragment to Lead (F2LTM) research tool series consists of molecules that have a molecular weight in the range of 250-350 Da. which makes this library ideal for generating high ligand efficiency hits as well as the progression of fragments into leads. This set can be used for normal HTS screens and also functions as a very convenient ready made tool for fragment growth and elaboration.
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BioDesign is only available upon request, please contact us at |
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| Latest News |
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Would you like to receive
ASINEX’s newest nature-
like compounds?
To make sure you are
included in the latest
updates, please contact
busdev@asinex.com
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