CNS

Product Name: Format/SizeDescriptionsDownload
CNS Library131014 compounds
For cherry-picking
Update: 2016-11
The file contains all available CNS biased compounds selected from our Signature & BioDesign Libraries. For more information, please download >>>sdf-icon sdf-icon
CNS Macrocycles2328 compounds
For cherry-picking
Update: 2017-11
For more information, please download >>>sdf-icon pdf-icon
CNS Diversity Pre-Plated Set6091 compounds
Pre-Plated Set
Amount: 0.01-2.0mg
Release: 2018-05
ASINEX has selected CNS-like molecules with high diversity:
CNS-MPO > 4
CNS-MPO.v2 > 4
CNS-TEMPO < 4
Example of scaffold diversity is in PDF, please download >>>
sdf-icon pdf-icon
SL#044
CNS set (PAMPA BBB)
80 compounds
Pre-Plated Set
Release: 2016
In-vitro screening of ASINEX’sBioDesigncollection has revealed a number of CNS-like molecules with high PAMPA-BBB permeability properties (Pe >10 x 10-6cm/s). A diversity-selection of the most permeable compounds has been used as the basis for this library which can be further expanded through available analogs.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#048
ApoE activators (agonist)
80 compounds
Pre-Plated Set
Release: 2016
A library of 15000 natural product like compounds has been screened in vitro in CCF-STTG (human astrocytoma) cells against ApoE secretion using an ELISA assay. A number of primary hits have been further optimized to provide compounds with ApoE secretion agonistic activity in the range of 0.6-15 µM.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#073
CNS kinase - DLK (MAP3K12)
80 compounds
Pre-Plated Set
Release: 2017
80 analogs of the reported hits have been included in this library. Structures are available,"click here"and downlaod "File#1 Signature Libraries.pdf-icon
SL#076
OxyTerpenoids for CNS
80 compounds
Pre-Plated Set
Release: 2017
ASINEX has developed a synthetic toolbox which has enabled us to generate a unique library of skeletally diverse terpenoid-like molecules.
These molecules are particularly interesting for CNS-related research due to favorable CNS-likeness properties: CNS-MPO score >4 and high PAMPA-BBB. Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#077
Morpholines for CNS
80 compounds
Pre-Plated Set
Release: 2017
Asinex has developed several novel lead-like morpholine-containing small molecules, that predictably demonstrate favorable CNS-like properties (CNSMPO > 4). Structures are available,"click here"and downlaod "File#1 Signature Libraries.pdf-icon
SL#078
Sympathomimetics chemical probes
80 compounds
Pre-Plated Set
Release: 2017
Asinex has developed several analogs of Propranolol - first clinically successful sympathomimetic, containing the characteristic 3-amino-2-hydroxypropanol fragment. Structures are available,"click here"and downlaod "File#1 Signature Libraries.pdf-icon
SL#079
Piperidines for CNS-1
80 compounds
Pre-Plated Set
Release: 2017
Asinex have created a series of novel piperidine containing molecules, that have favorable CNS-like physico-chemical properties making these compounds an interesting screening set for CNS-directed research. Structures are available,"click here"and downlaod "File#1 Signature Libraries.pdf-icon
SL#080
Analgesic for CNS
80 compounds
Pre-Plated Set
Release: 2017
Asinex has created several novel 3-substituted 2-benzylpiperidine derivatives that represent an interesting chemotype for studying opiod receptor signaling. Structures are available,"click here"and downlaod "File#1 Signature Libraries.pdf-icon
SL#091
Fatty Acid Amide Hydrolase
(FAAH) inhibitors            
80 compounds
Pre-Plated Set
Release: 2018
Synthetic inhibitors of FAAH have been explored as promising candidates for the treatment of several disease conditions including pain, inflammation and mood disorders. Several promising chemical series such as carbamates and arylureas, have been optimized and moved into clinical trials. Analogs of the reported clinical candidates were included into this library.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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Please click here for List of all Signature Libraries.

 

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