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BioDesign  04/2015 Update

Asinex's BioDesign approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analyses of structural features of natural products, marketed drugs, and drug candidates. Our research shows that saturated fused ring, spiro, and bridged systems with a tendency towards chirality are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. The basis of our BioDesign approach incorporates these highly privileged elements in the design of novel synthetic molecules to deliver screening compounds with a higher level of saturation (av.Fsp3>0.5), multiple chiral centers (av.≥2), and a high diversity of natural product-like frameworks.

116.563 compounds
SD File 32.7 Mb , Smiles 1.5 Mb
 
 
The Elite Libraries®  03/2015 Update stock availability

“Leadlikeness” is the basis of The Elite Libraries® which have been shown to be an excellent starting point in various drug discovery programs (e.g GPCR, Kinase, Ion Channels).This library includes >900 scaffolds designed with a focus on novelty and ease of medicinal chemistry development. The Elite Libraries® have been biologically profiled to avoid ADMET problems; this testing along with the fact that the compounds are amenable for rapid hit-to-lead optimization has lead to a number of documented success stories in drug discovery.

104.577 compounds
SD File 31.8 Mb , Smiles 1.6 Mb
 
 
Gold/Platinum Collection 03/2015 Update stock availability
296.537 compounds
SD File 90.3 Mb , Smiles 4.1 Mb
 
 
Fragments  04/2015 Update stock availability
36.598compounds
SD File 8.1 Mb , Smiles 0.5 Mb
Upon request:
1. Macrocyclic Pre-formatted set
2. Phenotypic Screening Set
 

 

 

 

For more information please contact ASINEX at:
Tel.: +1 877 ASINEX1 (Toll Free), +1 336 721 1617
E-mail : mparisi@asinex.com

 
 
 
 
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