Epigenetics

Product Name: Format/SizeDescriptionsDownload
Epigenetic Library6548 compounds
For cherry-picking
Update: 2016-11
The file contains all available Epigenetic compounds selected from ourSignature & BioDesign Libraries.For more information, please download >>>sdf-icon pdf-icon
SL#031
EZH2 inhibitors
80 compounds
Pre-Plated Set
Release: 2016
Using a combination of structure and ligand based design, ASINEX has created a library of aminomethyl quinolone-2 derivatives decorated by ortho-substituted heteroaromatic acids. The resulting amides share some similarity with published EZH2 inhibitors and may provide useful molecular probes for understanding EZH2 functional activity and developing novel, potent anti-cancer agents. For more information, please download >>>sdf-icon pdf-icon
SL#042
Protein lysine methyltransferase
80 compounds
Pre-Plated Set
Release: 2016
The Protein Data Bank has more than 1300 different PKMT entries in their apo- or small molecule-bound forms which provides a significant amount of information for de novo design of novel selective inhibitors. Additionally, new compounds with validated in vitro inhibitory activity toward PKMTs represent an attractive starting point for the rational creation of more effective inhibitors. In this library we highlight several compounds that demonstrate a μM range of activity against SETD8 – an emerging target for anti-cancer intervention. For more information, please download >>>sdf-icon pdf-icon
SL#045
HDAC inhibitors
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has screened a library of 50000 small molecules and identified a number of hits with significant HDAC (HeLa cell lysate) inhibitory activity. For more information, please download >>>sdf-icon pdf-icon
SL#047
BET inhibitors
80 compounds
Pre-Plated Set
Release: 2016
By utilizing a combination of ligand-based and structure-based design methods, ASINEX has created a library of novel compounds that were shown to inhibit BRD2 and BRD4 proteins in vitro. For more information, please download >>>sdf-icon pdf-icon

 

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Product Name: Format/SizeDescriptionsDownload
Nucleoside Mimetics3866 compounds
For cherry-picking
Update: 2016-11
ASINEX has developed a number of stereo- and enantio-selective methods for the synthesis of nucleoside-like core intermediates (e. g. mimics of adenosine). These unique intermediates have been extensively decorated by various long chain amines, acids and amino acids. For more information, please download >>>sdf-icon pdf-icon
SL#010, 052
Purine-based Nucleosides
80 compounds x 2
Pre-Plated Set
Release: 2016
Compounds targeting the SAM/SAH site of these enzymes offer great potential, yet very few such molecules are currently described in literature or commercially available in compound collections. To address this market need, ASINEX has used a modular approach to synthesize a library of purine-based nucleosides. The main challenge was to develop stereo- and enantio-selective methods for the synthesis of nucleotide-like cores which both mimic adenosine and are metabolically stable. For more information, please download >>>sdf-icon pdf-icon

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