Ion-Channel

Product Name: Format/SizeDescriptionsDownload
Ion-Channel Library10731 compounds
For cherry-picking
Update: 2018-01
The file contains all available Ion-Channel compounds selected from our Signature & BioDesign Libraries. For more information, please download >>>sdf-icon pdf-icon
SL#005, 051
Ion Channel Modulators. Nav1.8
80 compounds x 2
Pre-Plated Set
Release: 2016
Based on the analysis of several known NaV1.8-blockers ASINEX has developed a pharmacophore model which has been used to carry out an exhaustive search on a 20000+ set of natural product-like compounds. The highest scoring compounds were screened in vitro in the human Nav1.8/β3 sodium channel cell line.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#092
Ion Channel Modulators Nav1.7
80 compounds
Pre-Plated Set
Release: 2018
A recent study reported a series of pyrrolopyrimidine derivatives as highly potent and state-dependent inhibitors of Nav1.7. Analogs of the reported chemotypes were included into this library.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#041
Voltage-gated sodium channels
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has identified a number of ion-channel modulators against undisclosed voltage-gated ion channels. This library is useful for ion channel research and drug discovery.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#064
TMEM16A Channel Modulators
80 compounds
Pre-Plated Set
Release: 2017
Transmembrane protein 16A (TMEM16A) inhibitors have been proposed for treatment of disorders of epithelial fluid and mucus secretion, hypertension, asthma, and possibly cancer. A recent study revealed that a series of 2-acylaminocycloalkylthiophene-3-carboxylic acid arylamides can inhibit TMEM16A at low nM concentrations. 80 close analogs of the most potent inhibitor 10bm were included into this library.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#081
Aankyrin-like receptor family
(TRPA1) Agonists 
80 compounds
Pre-Plated Set
Release: 2018
A recent study reported several electrophilic compounds that covalently modify reactive cysteine residues revealing important insights about the key SH groups involved in TRPA1 activation. Analogs of the reported molecules were included into this library.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#084
Inhibitors of TRPC3/6/7    
80 compounds
Pre-Plated Set
Release: 2018
A series of pyrazolopyrimidine derivatives has been recently discovered as potent agonists of TRPC3/6/7 channels. Structural analogs of the reported ion channel modulators were included into this library.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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