Kinase

Product Name: Format/SizeDescriptionsDownload
Kinase Library6538 compounds
For cherry-picking
Update: 2016-11
ASINEX facilitates the discovery of novel kinase inhibitors by providing access to our advanced collection of small molecules, fragments and macrocycles. The efficacy of our compounds has been validated through in silico modeling and in vitro on-target and phenotypic profiling. This is paralleled with 20+ years of medicinal chemistry expertise, delivering designs with outstanding ADMET and PK properties, optimizing chances in hit to candidate development. For more information, please download >>>sdf-icon pdf-icon
Kinase Type II Inhibitors2619 compounds
For cherry-picking
Update: 2017-08
ASINEX has designed molecules that could act as Type-II Kinase ligands using a proprietary computational algorithm. For more information, please download >>>sdf-icon pdf-icon
SL#015
Ser-Thr Kinases
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has designed molecules that in vitro target a number of Ser-Thr Kinases including Aurora A, Aurora B, Haspin, and B-Raf. For more information, please download >>>sdf-icon pdf-icon
SL#026
IRAK4 inhibitors
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a series of IRAK4-oriented compounds by combining the IRAK4 hinge binding motif with proprietary natural product-like fragments. Several compounds from this library were screened against IRAK4 kinase in vitro and showed sub-uM IC50. Sunitinib was also included in the library as a reference compound. For more information, please download >>>sdf-icon pdf-icon
SL#046
EGFR, PDGFR alpha & beta inhibitors
80 compounds
Pre-Plated Set
Release: 2016
Screening of the ASINEXBioDesign Librarieshas revealed a number of potent (IC50 < 1µM) inhibitors of EGFR and PDGFRɑ/β . This library is a useful starting point for kinase-oriented research and drug discovery. For more information, please download >>>sdf-icon pdf-icon
SL#073
CNS kinase - DLK (MAP3K12)
80 compounds
Pre-Plated Set
Release: 2017
Structures (SDF) is now available >>>sdf-icon
SL#074
PKCε translocation inhibitors
80 compounds
Pre-Plated Set
Release: 2017
Structures (SDF) is now available >>>sdf-icon

Please click here for List of all Signature Libraries.

 

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