GPCR

Product Name: Format/SizeDescriptionsDownload
GPCR Library10452 compounds
For cherry-picking
Update: 2016-11
The file contains all available GPCR compounds selected from our Signature & BioDesign Libraries. For more information, please download >>>sdf-icon pdf-icon
Lipid GPCR Library3050 compounds
Update: 2016-11
The file contains ALL Lipid GPCR compounds for cherry-picking. For more information, please download >>>sdf-icon pdf-icon
Peptide GPCR Library
(Macrocycles)
12075 compounds
Release: 2016-11
The file contains ALL Peptidergic GPCR macrocycles for cherry-picking. For more information, please download >>>sdf-icon pdf-icon
SL#014
Peptide GPCRs, SST4R agonists
80 compounds
Pre-Plated Set
Release: 2016
ASINEX's GPCR screening platform including an SST4 binding assay, SST4 GTPγS assay, and SST4 cell functional assays, has identified several potent modulators of SST4R.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
pdf-icon
SL#078
Sympathomimetics chemical probes
80 compounds
Pre-Plated Set
Release: 2017
Asinex has developed several analogs of Propranolol - first clinically successful sympathomimetic, containing the characteristic 3-amino-2-hydroxypropanol fragment. Structures are available,"click here"and downlaod "File#1 Signature Libraries.pdf-icon
SL#088
Free Fatty Acid Receptor
(FFAR) Regulators  
80 compounds
Pre-Plated Set
Release: 2018
Known small molecule agonists of FFA receptors share some common pharmacophoric features, such as a carboxylic acid moiety attached directly or via an aliphatic tail to an aromatic core. A pharmacophore search through ASINEX’s compound collection identified several hits that can be explored for FFA research and drug discovery.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
pdf-icon
SL#089
Dopamine receptor type 2
(DRD2) inhibitors  
80 compounds
Pre-Plated Set
Release: 2018
Several recent studies demonstrated that dopamine receptors D2 are associated with tumorigenesis. Some antipsychotic drugs showed anti neoplastic effects on human cancers as adjuvants enhancing the effi¬cacy of anticancer therapy in breast and colon cancer cell lines. A pharmacophore search through ASINEX’s compound collection identified several molecules that can be explored for GPCR research and anticancer drug discovery.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
pdf-icon
SL#090
κ-Opioid receptor (KOR) agonists     
80 compounds
Pre-Plated Set
Release: 2018
Recent report shows a novel chemical series of KOR agonists based on a triazole scaffold. The lead compound Triazole 1.1 was tested in vivo and demonstrated a preservation of the analgesic properties with no signs of the sedating or dysphoric effects of typical KOR agonists.
Analogs of the reported triazole lead series were included into this library.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
pdf-icon

Please click here for List of all Signature Libraries.

 

Top