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| Home > BioDesign > BioDesign F2LTM |
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| BioDesign F2LTM |
ASINEX's Fragment to Lead (F2L) library consists of 12,000 very diverse small molecules based on 260 unprecedented scaffolds. All BioDesign F2LTM compounds conform to very strict lead-like criteria: MW ?350 Da, ClogP ? 3 etc. ASINEX has applied it's know-how in carbon-carbon bond formation chemistry, asymmetric synthesis and metal-catalyzed reactions to create molecules containinga variety of privileged structural elements of natural products.
BioDesign F2LTM is a unique research tool for generating high ligand efficiency hits as well as the progression of fragments into leads. Due to exceptionally high aqueous and DMSO solubility, the F2L compounds are ideal for screening in either biochemical or biophysical assays. The F2L library has been divided into 6 subsets, please click on the links below to learn more about each of them: |
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| BioDesign F2LTM (Fragment to Lead) |
Sub-library |
Size |
MW |
cLogP |
RB |
HBA |
HBD |
TPSA |
BioDesign F2LTM |
12,000 |
250-350
MW |
≤ 3 |
≤ 6 |
≤ 7 |
≤ 3 |
≤ 100 |
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| Oxy Set |
A collection of 2,000 small molecules based on 25 unprecedented oxygen-enriched saturated scaffolds. |
| Shape Enhancer |
A set of 500 unprecedented diverse molecules with a specific 3D-geometry which enables the coverage of under-explored areas of the shape universe. |
| SpiroCore |
A set of 2000 molecules based on 40 unprecedented scaffolds containing a 'spiro' framework as a central core. |
| StereoCore |
A set of 2500 molecules based on 40 unprecedented scaffolds containing a saturated aza-bicyclic system as a central core. |
| BioCore |
A set of 5,000 molecules based 250 scaffolds that contain the 'BioCore' motif of a saturated ring connected to an aromatic ring by a carbon-carbon bond. |
| HCS Subset |
(High Concentration Screening)
A subset of 8,000 compounds from BioFragments and F2L |
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| BioDesign is only available upon request, please contact us at |
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like compounds?
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