Asinex Elite Libraries

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Elite Libraries

The Elite Libraries have been developed in order to tackle one of the bottle-necks of drug discovery: the fact that only a handful of initial hits will progress to the stage of lead optimization and beyond. ASINEX is improving the quality of the screening pool in order to rectify this bottleneck. Another important feature is a high level of follow up services, as the compounds are all in-house designed and synthesized we can provide protocols for all compounds and offer efficient refill supply.

72,500 compounds / 880 scaffolds / Double QC / Rule of 4.5 / Exceptional Novelty

The Elite Libraries is composed of several sub-collections each of which has its own particular characteristics

Please click on any of the logos for more information and example structures

	Diamond	Emerald	Opus
General Diversity

	Spacer Fragment Library	Spacer Fragment Assembler	IP Explorer
Lead Optimization Features

	LeadMax Kinase	LeadMax GPCR
Targeted Libraries

	Spiro Chemistry	Asymmetry Array
Rigid & Chiral Compounds

	Rule of 3 Array
Fragments

Novelty – 60% of templates have no references in scientific literature

Drug-Likeness – strict structural filters have been implemented at the design stage

Solubility – 80% of compounds have greater than 100 µg/ml in a medium of PBS

ADMET – representative clusters have been probe screened for toxicity (CYP) and permeability (PAMPA + PGP)

Elite Libraries (72,500 compounds / 880 scaffolds)
Sub-library	Size	MW	cLogP	Description
General Diversity	35500	≤ 450	≤ 4.5	60% of scaffolds are unprecedented in SciFinder and Beilstein. In addition to the exceptional novelty there is a high degree of diversity.
Lead Optimization Features	10000	≤ 450	≤ 4.5	3 or 4 fragment compounds that enable fast & efficient optimization. Medicinal chemists are able to rapidly progress these compounds.
LeadMax Kinase	9000	≤ 450	≤ 4.5	All ASINEX LeadMax Kinase compounds have been screened against a panel of more than10 kinases. Each scaffold has shown activity against at least one target.
LeadMax GPCR	7000	≤ 450	≤ 4.5	All ASINEX LeadMax GPCR compounds have been screened against a panel of more than10 GPCRs. Each scaffold has shown activity against at least one target.
Spiro, Cage & Chiral	6500	≤ 450	≤ 4.5	This set consists of spiro, cage & chiral compounds. This class of compound is dramatically under-represented among commercial sources and is a useful addition to any compound library.
Rule of 3 Array	4500	≤ 300	≤ 3.0	All Elite Library compounds which have a MW of less then 300. This set is ideal for fragment based screening and most compounds have solubility in PBS of <100mg/ml.

Sub-Library	Template	Compounds	Compounds
General Diversity
General Diversity
Lead Optimization Features
Lead Optimization Features
LeadMax Kinase
LeadMax Kinase
LeadMax GPCR
LeadMax GPCR
Spiro, Cage & Chiral
Spiro, Cage & Chiral
Rule of 3 Array
Rule of 3 Array

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