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Gold, Platinum & Building Blocks

Diverse Sets & Targeted Libraries

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Gold and Platinum Collections

The Gold Collection started in 1994 with the collecting of compounds from former Soviet universities and research institutes and supplying them on to Western Pharma and Biotech companies. It is an extremely diverse library which we estimate covers 85% of the chemical space of other historical libraries. The Gold Collection consists of 250,000 compounds and its greatest strength is the level of diversity.

In 1998 ASINEX set up its own laboratory and started producing in-house synthesized compounds. This became known as the Platinum Collection. This collection is generally more lead-like than the Gold Collection and as it is an in-house collection we are able to provide more efficient follow-up services. The Platinum Collection consists of 150,000 compounds which are only available from ASINEX.

All recently acquired or synthesized compounds in the Platinum and Gold Collections must conform to 16 structural and drug-like descriptors, in particular Lipinski’s rule of 5.

Properties

The majority of compounds have a high degree of drug-likeness, in accordance with ‘Lipinski’s Rule of 5’:

The diversity analysis carried out by Irwin and Shoichet, J. Chem. Inf. Model. 2005;45(1):177-82 and visible on the ZINC website http://zinc.docking.org/vendor0 shows these libraries in a favourable light in terms of diversity and drug-likeness.

ASINEX Standard Building Blocks

ASINEX’s standard Building Blocks are reagents ideal for combinatorial chemistry and lead optimization; they are typical fragmented drug-like building blocks which have several points of diversity. This collection of 7000 compounds consists mainly of Primary Amines, Secondary Amines, Carboxylic Acids, Aldehydes and Polyfunctional Building Blocks.

Our building blocks are exceptionally diverse and drug-like and make superb tools for decoration or library expansion. Included are many peripheral building blocks with low molecular weight which are ideal for lead optimization, and many may also suitable for fragment-based screening.

Properties

The quality of the Drug-Like Building Blocks is exceptionally high with a minimum purity of 95% and an average of 98%. been tested for stability and solubility in DMSO, and are available as dry powder.

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