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| Home > Libraries > Synergy |
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| Synergy |
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 Synergy is ‘the interaction of two or more agents or forces so that their combined effect is greater than the sum of their individual effects’
ASINEX has developed a high diversity library of 35,000 compounds rich in drug-like pharmacophore fragments. The design of this library is based on a combination of two forms of Synergy. The first is an inter-relationship between diversity and target orientated techniques, and secondly the convergence of multi-step key intermediates in order to create sophisticated compounds (6-9 steps).
6000+ key intermediates have used in a wide range of convergent synthesis reactions in order to create a library of impressive diversity. The starting points for the design were training sets of known leads for several target classes. Attractive pairs of intermediates were identified using ASINEX’s pharmacophore hierarchy analysis algorithm. |
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| In terms of diversity, we believe it is the perfect tool for discovering new leads for novel targets when ideally a probe library should cover a wide area of chemical space. In addition to being exceptionally diverse, the library is highly novel due to the coupling of two rare intermediates. This is an ideal probe library for generating initial hits for a new screening campaign. Targeted subsets (kinases, GPCRs, CNS, proteases, ion channels) are ideal for a more focused approach. |
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Properties
The compounds have a high degree of drug-likeness, following parameters which we have called ‘the rule of 4 and a quarter’: MW ≤ 425, cLogP ≤ 4.25, number of HB donors ≤ 4, HB acceptors ≤ 8, and RB ≤ 8 |
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