|Agrochem & Crop Protection||13983 compounds|
|ASINEX offers access to its innovative chemistry for application in agriculture, horticulture, forestry, and public health. ASINEX’s expertise in synthetic and natural product chemistry combined with long-term business relations with multiple crop protection and agrochemical companies creates a strong foundation for delivering valuable starting points for the discovery of effective fungicides, herbicides, insecticides, and other useful active ingredients. For more information, please download >>>|
|Asinex in ChEMBL & SureChEMBL||81413 compounds|
|ASINEX’s compounds appear in Literature references as well as Patents on a regular basis. Often, the fact that these compounds originate from our catalogue is explicitly mentioned in these publications. It is an important external validation of the quality and relevance of our designs for the current Drug Discovery efforts by the Drug Discovery Community. For more information, please download >>>|
|Nuclear Receptors||6404 compounds|
|ASINEX have designed Nuclear Receptor oriented screening library based on the analysis of NR-privileged scaffolds and ring systems combined with molecular descriptor profiling. |
In order to eliminate bias towards a particular NR family we have performed a diversity analysis and reduced the number of overpopulated clusters; additionally, we have added examples of rare and structurally novel scaffolds. For more information, please download >>>
|Leishmania tryparedoxin peroxidases (LmTXNPx) are essential for parasite survival in the host making these enzymes an attractive drug target for the treatment of leishmaniasis. A series of N,N-disubstituted 3-aminomethyl quinolones was recently reported as potent non-covalent inhibitors of LmTXNPx. 80 close analogs of the reported inhibitors were included in this library. |
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
|One of the most common mutations is ΔF508-CFTR which leads to the CFTR loss of function. A group headed by Dr. Kurth published a series of cyanoquinolines, small molecules that act as a corrector of ΔF508-CFTR, targeting the plasma membrane and potentiator of ΔF508-CFTR-mediated chloride channel activity. Compounds with potentiator-only, corrector-only, and dual potentiator–corrector activities were disclosed . |
80 analogs of the reported hits were included in this library. Structures are available,"click here"and downlaod "File#1 Signature Libraries.
Sympathomimetics chemical probes (CV)
|Asinex has developed several analogs of Propranolol - first clinically successful sympathomimetic, containing the characteristic 3-amino-2-hydroxypropanol fragment. Structures are available,"click here"and downlaod "File#1 Signature Libraries.|
Please click here for List of all Signature Libraries.