Publications

Poster: Compound-to-Target™ platform – small molecule discovery engine for difficult targets.

Mark Parisi, Roman Kombarov, Ramon Jimenez-Moreno, Dmitry Genis
November, 16-17, 2015, 4th Oncology Partnering & Deal-Making Conference, San Francisco CA USA / 4OP&DMC2015.pdf
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Poster: ASINEX Signature Libraries™ A Unique Direction in Early Drug Discovery Research

Mark Parisi, Roman Kombarov, Dmitry Genis
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Poster: Identification and preliminary structure–activity relationships of novel pyrrolidinyl pyrimidine inhibitors of the Bcl-2 family of antiapoptotic proteins.

S. Breining, A. Shirokov, R. Jimenez-Moreno, O. Roberts, A. Rzepiela, and V. Kochubey.
August, 19, 2015, American Chemical Society 250th National Meeting, Boston, MA, USA / ACS2015.pdf
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General Ser/Thr Kinases Pharmacophore Approach For Selective Kinase Inhibitors Search As Exemplified By Design Of Potent And Selective Aurora A Inhibitors.

Vasilevich NI, Aksenova EA, Kazyulkin DN, Afanasyev II. / Chem Biol Drug Des. 2016 Jan 30 / DOI: 10.1111/cbdd.12733
A Re-examination of the MDM2/p53 Interaction Leads to Revised Design Criteria for Novel Inhibitors.

Vasilevich NI1, Afanasyev II, Kovalskiy DA, Genis DV, Kochubey VS.
Chem Biol Drug Des. 2014 May 2 / DOI: 10.1111/cbdd.12351.
Dual mode of action of Phenyl-Pyrazole-Phenyl (6-5-6 system) based PPI inhibitors: alpha-helix backbone versus alpha-helix binding epitope.

Natalya Ivanovna Vasilevich, Ilya Afanasyev, Eugene Rastorguev, Dmitry Genis and Valery Kochubey
Med. Chem. Commun., 2013, Accepted Manuscript / DOI: 10.1039/C3MD00211J
Determination of flomoxef in human plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.

Oxana Yu Kravtsova, Sergey A Paramonov, Natalya I Vasilevich, Denis N Kazyulkin, Ekaterina Vlasova, Michael Engsig
Biomedical Chromatography, 2013, Volume 27, Issue 12, pp 1609–1614 / DOI: 10.1002/bmc.2968
Oxygen-containing fragments in natural products.

Zoya Titarenko, Natalya Vasilevich, Vladimir Zernov, Michael Kirpichenok, Dmitry Genis
J. Comput. Aided Mol. Des., 2013, Feb;27(2), pp 125-160. / DOI: 10.1007/s10822-012-9629-z
Lessons from natural products chemistry can offer novel approaches for synthetic chemistry in drug discovery.

Natalya I Vasilevich, Roman V Kombarov, Dmitry V Genis, Michael A Kirpichenok
J. Med. Chem., 2012, 55 (16), pp 7003–7009 / DOI: 10.1021/jm300344v
Lessons from natural products chemistry can offer novel approaches for synthetic chemistry in drug discovery.

Natalya I Vasilevich, Roman V Kombarov, Dmitry V Genis, Michael A Kirpichenok
J. Med. Chem., 2012, 55 (16), pp 7003–7009 / DOI: 10.1021/jm300344v
Design, Synthesis, and Antiviral Activity of Entry Inhibitors That Target the CD4-Binding Site of HIV-1.

F. Curreli, S. Choudhury, I. Pyatkin, V. Zagorodnikov, A. Bulay, A. Altieri, Y.D. Kwon, P.D. Kwong, A. K. Debnath
J. Med. Chem., 2012, 55 (10), pp 4764–4775 / DOI: 10.1021/jm3002247
A minimalist fragment approach for the design of natural-product-like synthetic scaffolds.

Dmitry Genis, Mikhail Kirpichenok, Roman Kombarov
Drug Discovery Today, 2012, Volume 17, 21–22, pp 1170–1174. / DOI: 10.1016/j.drudis.2012.05.013.
BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery.

Kombarov Roman, Altieri Andrea, Genis Dmitry, Kirpichenok Mikhail, Kochubey Valery, Rakitina Natalia, Titarenko Zoya.
Molecular Diversity, 2010 14(1, pp 193-200. / DOI: 10.1007/s11030-009-9157-5.

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