RNA-Binding

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SL#063
Preferred RNA-binding motifs
2-phenyl benzimidazole
80 compounds
Pre-Plated Set
Release: 2017
A small molecule Targapremir-210 belonging to the 2-phenyl benzimidazole scaffold was shown to bind to the Dicer site of the miR-210 hairpin precursor inhibiting production of the mature miRNA. miR-210 regulates hypoxia inducible factors and plays a critical role in cancer maintenance. Small molecules that can selectively target specific miRNAs are promising therapeutic agents against several cancers.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#066
Inhibitors of miсroRNA-21
80 compounds
Pre-Plated Set
Release: 2017
Small molecules that can bind directly to miR-21 have been suggested as a promising new therapy for the treatment of cancer. Screening a large library of druglike small molecules has identified several chemotypes that bind to the pre-miR-21 hairpin with high selectivity against other oligonucleotides. The most potent hit molecules share the common 1-amino-3-(9H-carbazol-9-yl)propan-2-ol scaffold which can be considered a privileged fragment.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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SL#067
Inhibitors of miсroRNA-29
80 compounds
Pre-Plated Set
Release: 2017
It has been hypothesized that compounds having at least one basic nitrogen are favored due to possible electrostatic interaction with negatively charged RNAs. In a paper submitted by the Prof. Nakatani group, several small molecules were disclosed exhibiting detectable affinity to pre-miR-29a - a miRNA involved in multiple pathophysiological processes. Analogs of one of the hit molecules (S-6) have been included in this library.
Structures are available,"click here"and downlaod "File#1 Signature Libraries.
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