ADMET Screening

ASINEX offers a complete ADMET screening schedule. In order to review our great prices please download our complete brochure (pdf 182Kb).

Solution properties:

• Aqueous solubility
• Partition coefficient
• Chemical stability

In vitro absorption:

• P-glycoprotein inhibition
• PAMPA

In vitro metabolism/Toxicity:

• CYP-450 inhibition: CYP 1A2 / CYP 2C9 / CYP 2C19 / CYP 2D6 / CYP 3A4

In vitro metabolism/Metabolic stability:

• CYP-450
• Microsomes
• S9 fraction
• Hepatocytes
• Half-life determination
• Plasma stability

Cytotoxicity

• Cell viability: human hepatocellular carcinoma cells (Hep G2) / human primary hepatocytes / rat primary hepatocytes

Herg inhibition: [H3] astemizole binding to membranes of HERG transfected HEK293 cells

Proliferation and Apoptosis:

18 cell lines: U 937, K 562, Jurkat, HL-60, MT-4, IM-9, А172, IMR-32, MCF-7, Hela, CaCo-2, Colo320HSR, A 549, WI - 38, RD, Capan-2, SW 837, A431)

ASINEX also offers

• Primary screening
• IC50 determination
• Cell-based assays

We have a range of kinases, GPCRs, protease and some other assays established in-house, please enquire for details. As part of an integrated project we are ready to perform selection followed by screening and last but not least chemistry.

Please download our complete brochure (pdf 182Kb)


To receive a quote or for more info please contact us at 7 495 780 3417