Soft Electrophiles

 

Product Name: Format/SizeDescriptionsDownload
Soft Electrophiles8209 compounds
For cherry-picking
Update: 2016-11
The file contains all available Soft Electrophiles selected from ourSignature & BioDesign Libraries.For more information, please download >>>sdf-icon pdf-icon
SL#019
Soft Electrophiles-1
(acrylamide derivatives)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of acrylamide derivatives by combining proprietary glycomimetic or peptidomimetic fragments with selected amino acrylic acids known as “soft” electrophiles that bind to Cys residues. For more information, please download >>>sdf-icon pdf-icon
SL#020
Soft Electrophiles-2
(heterocylic cinnaminc acid)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of heterocylic cinnaminc acid derivatives by coupling with proprietary fragments. Cinnamic acid and its derivatives are found among natural products that are known for their anti-inflammatory, anti-cancer, and cardio-protective properties. [1] For more information, please download >>>sdf-icon pdf-icon
SL#022
Soft Electrophiles-3
(kinase+hetero-cinnamic acids)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of kinase-oriented small molecules by attaching electrophilic hetero-cinnamic acids to various kinase hinge-binding scaffolds. It is hypothesized that a Michael acceptor moiety of cinnamic acid is able to interact with Cys residues presented at the binding site. The resulting set represents a unique research tool for the discovery and optimization of new inhibitors across the kinome. For more information, please download >>>sdf-icon pdf-icon
SL#027
Soft Electrophiles-4
(ɑ-oxyketone and spiro-lactone)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of ɑ-oxyketone and spiro-lactone derivatives that contain mild electrophilic functional groups. Both lactones and oxyketones provide interesting small molecule probes for covalent drug discovery across multiple disease areas [2] as they interact with nucleophilic residues (e.g. Ser, Thr, Lys and Cys) of target proteins. For more information, please download >>>sdf-icon pdf-icon
SL#037
Soft Electrophiles-5
(heteroaromatic nitrile derivatives)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of heteroaromatic nitrile derivatives which have kinase-oriented pharmacophoric elements. These compounds are useful for the discovery of novel kinase inhibitors with improved safety, target selectivity, and pharmacokinetic properties. For more information, please download >>>sdf-icon pdf-icon

References:

 

[1] Nutr Rev. 2011 Jun;69(6):310-20. doi: 10.1111/j.1753-4887.2011.00394.x.
[2] Current Opinion in Chemical Biology 2010, 14:421–427 doi:10.1016/j.cbpa.2010.03.035  

 

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