Soft Electrophiles

 

Product Name: Format/SizeDescriptionsDownload
Soft Electrophiles8209 compounds
For cherry-picking
Update: 2016-11
The file contains all available Soft Electrophiles selected from our Signature & BioDesign Libraries. For more information, please download >>>sdf-icon pdf-icon
SL#019
Soft Electrophiles-1
(acrylamide derivatives)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of acrylamide derivatives by combining proprietary glycomimetic or peptidomimetic fragments with selected amino acrylic acids known as “soft” electrophiles that bind to Cys residues.
Structures are available,"click here"and downlaod "File#1 (1/5) Signature Libraries.
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SL#020
Soft Electrophiles-2
(heterocylic cinnaminc acid)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of heterocylic cinnaminc acid derivatives by coupling with proprietary fragments. Cinnamic acid and its derivatives are found among natural products that are known for their anti-inflammatory, anti-cancer, and cardio-protective properties. [1]
Structures are available,"click here"and downlaod "File#1 (1/5) Signature Libraries.
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SL#022
Soft Electrophiles-3
(kinase+hetero-cinnamic acids)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of kinase-oriented small molecules by attaching electrophilic hetero-cinnamic acids to various kinase hinge-binding scaffolds. It is hypothesized that a Michael acceptor moiety of cinnamic acid is able to interact with Cys residues presented at the binding site. The resulting set represents a unique research tool for the discovery and optimization of new inhibitors across the kinome.
Structures are available,"click here"and downlaod "File#1 (1/5) Signature Libraries.
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SL#027
Soft Electrophiles-4
(ɑ-oxyketone and spiro-lactone)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of ɑ-oxyketone and spiro-lactone derivatives that contain mild electrophilic functional groups. Both lactones and oxyketones provide interesting small molecule probes for covalent drug discovery across multiple disease areas [2] as they interact with nucleophilic residues (e.g. Ser, Thr, Lys and Cys) of target proteins.
Structures are available,"click here"and downlaod "File#1 (1/5) Signature Libraries.
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SL#037
Soft Electrophiles-5
(heteroaromatic nitrile derivatives)
80 compounds
Pre-Plated Set
Release: 2016
ASINEX has created a library of heteroaromatic nitrile derivatives which have kinase-oriented pharmacophoric elements. These compounds are useful for the discovery of novel kinase inhibitors with improved safety, target selectivity, and pharmacokinetic properties.
Structures are available,"click here"and downlaod "File#1 (1/5) Signature Libraries.
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References:

 

[1] Nutr Rev. 2011 Jun;69(6):310-20. doi: 10.1111/j.1753-4887.2011.00394.x.
[2] Current Opinion in Chemical Biology 2010, 14:421–427 doi:10.1016/j.cbpa.2010.03.035  

 

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