Macrocycles

Product Name: Format/SizeDescriptionsDownload
Macrocycles29235 compounds
For cherry-picking
Update: 2017-05
ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel and have allowed us to generate tremendously diverse, medchem-relevant, macrocyclic frameworks. Many of our macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay. For more information, please download >>>sdf-icon pdf-icon
Macrocyclic Glycomimetics2048 compounds
For cherry-picking
Update: 2017-05
Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites. For more information, please download >>>sdf-icon pdf-icon
SL#008, 016, 036, 039
Macrocyclic Glycomimetics
80 compounds x 4
Pre-Plated Set
Release: 2016
Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites. For more information, please download >>>sdf-icon pdf-icon
SL#009
Cell Permeable Macrocycles
80 compounds
Pre-Plated Set
Release: 2016
This library has been tested in PAMPA assays and show permeability Pe greater than 4-16*10-6 cm/s. Generally, such compounds have excellent cellular permeability. For more information, please download >>>sdf-icon pdf-icon
SL#032
Macrocyclic BH3 mimetics
80 compounds
Pre-Plated Set
Release: 2016
Extensive in vitro screening of the Asinex Macrocyclic collection has revealed a series of molecules showing a μM range of activity against anti-apototic proteins Bcl-2 and Mcl-1. In silico modeling studies suggest that some active macrocycles can adopt a-helix-mimetic conformations that effectively mimic the BH3-epitope of pro-apoptotic peptides (e.g. Bak, Bax). For more information, please download >>>sdf-icon pdf-icon
SL#034
Macrocyclic β-turn mimetics
80 compounds
Pre-Plated Set
Release: 2016
Asinex has created a library of partially peptidic macrocyclic beta-turn mimetics that are able to reproduce the orientation of key amino-acid side chains forming a b-turn-like motif. For more information, please download >>>sdf-icon pdf-icon
SL#035
Oncology Phenotypic Screening-3
80 compounds
Pre-Plated Set
Release: 2016
ASINEX, has evaluated the susceptibility of several cancer cell lines (i.e. RKO, HCT116, Molt-4, Rs4-11, U937, A549, H1568, H23, PANC1, A2780) to an array of peptidic and non-peptidic macrocycles and identified a series of compounds that kill cancer cells at µM concentrations. For more information, please download >>>sdf-icon pdf-icon

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