Pre-Plated / Phenotypic Sets

Pre-Plated Sets: Format/SizeDescriptionsDownload
Macrocycle Pre-Plated Set21807 compounds
Pre-Plated Set
Amount: 0.01-2.0 mg
Update: 2017-01
ASINEX ‘s Macrocycle Pre-plated Sets are designed to provide the most popular screening libraries in a convenient and cost-effective manner. For more information, please download >>>sdf-icon pdf-icon
PPI Pre-Plated Set8639 compounds
Pre-Plated Set
Amount: 0.01-2.0 mg
Update: 2017-01
ASINEX has been working on the design and synthesis of protein-protein interaction (PPI) libraries since 2008. The latest generation of ASINEX PPI Library comprises molecules of various sizes, frameworks, and shapes ranging from fragment-like entities to macrocyclic derivatives designed as secondary structure mimetics or as epitope mimetics. For more information, please download >>>sdf-icon pdf-icon
Glycomimetics Pre-Plated Set2439 compounds
Pre-Plated Set
Amount: 0.01-2.0 mg
Update: 2017-01
ASINEX has overcome these obstacles by creating a glycomimetic library that ensures the bioactive function of carbohydrates while addressing the drawbacks of carbohydrates, such as their low activity and poor drug-like properties. For more information, please download >>>sdf-icon pdf-icon
Covalent Inhibitors Pre-Plated Set1000 compounds
Pre-Plated Set
Amount: 0.01-2.0 mg
Update: 2017-01
ASINEX has crafted a unique set of 1000 molecules containing electophylic moieties that could potentially interact with cysteine residues in the target protein. The diversity of represented scaffolds creates multiple opportunities for drug discovery in various target and therapeutic areas such as kinases, proteases, protein-protein interactions, and antimicrobials. For more information, please download >>>sdf-icon pdf-icon
Diversity Pre-Plated Set82993 compounds
Pre-Plated Set
Amount: 0.01-2.0 mg
Update: 2017-03
Pre-Plated Set of compounds selected from ASIENX BioDesign Libraries, Elite Libraries, Synergy Libraries, Gold&Platinum Collections. For more information, please download >>>sdf-icon
Phenotypic Screening Sets: Format/SizeDescriptionsDownload
Phenotypic Pre-Plated Set14720 compounds
Pre-Plated Set
Amount: 0.01-2.0 mg
Update: 2017-01
ASINEX has created a diverse set of molecules by applying strict physico-chemical and structural descriptors to ensure good solubility and permeability properties. For more information, please download >>>sdf-icon pdf-icon
SL#004
Oncology Phenotypic Screening-1
(Non-Macrocycle)
80 compounds / set
Pre-Plated Set
Release: 2016
ASINEX's oncology-oriented phenotypic library includes compounds based on several scaffolds with proven cytotoxicity (sub-µM EC50 in MTT assay) against a number of cancer cell lines: MV-411 (acute monocytic leukemia), HCT-116 (human colon cancer), MCF-7 (human breast adenocarcinoma‎), A-172 (Human glioblastoma), COLO-320 (colorectal adenocarcinoma), U-937 (histiocytic lymphoma), A-375 (malignant melanoma), BXPC-3 (pancreas adenocarcinoma), U118-MG (malignant glioma), and LN-229 (glioblastoma). Some active compounds were screened in a biochemical assay showing nM level of IC50 against several kinases: Aurora A, Haspin, VEGFR, EGFR, PDGFR. For more information, please download >>>sdf-icon pdf-icon
SL#023
Oncology Phenotypic Screening-2
(Colon Cancer/Non-Macrocycle)
80 compounds / set
Pre-Plated Set
Release: 2016
ASINEX has evaluated the susceptibility of several colon cancer cell lines (HCT-116, SW-620, COLO-320, RKO) to a diverse array of small molecules and identified a series of related compounds that kill cancer cells at sub-µM concentrations with limited off target effect on healthy cells (human fibroblasts). Additional screening in a cell-based luciferase reporter assay of Wnt signaling has provided preliminary evidence of Wnt-dependent mechanism of action. For more information, please download >>>sdf-icon pdf-icon
SL#035
Oncology Phenotypic Screening-3
(Macrocycles)
80 compounds / set
Pre-Plated Set
Release: 2016
ASINEX has evaluated the susceptibility of several cancer cell lines (i.e. RKO, HCT116, Molt-4, Rs4-11, U937, A549, H1568, H23, PANC1, A2780) to an array of peptidic and non-peptidic macrocycles and identified a series of compounds that kill cancer cells at µM concentrations. For more information, please download >>>sdf-icon pdf-icon

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