Antiviral

Antiviral

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Antiviral Library	6827 compounds For cherry-picking Update: 2020-07	The design and discovery of novel chemical entities with profound antiviral activity and improved safety profiles requires an access to high quality screening compounds that could deliver a meaningful starting point for further development. ASINEX has developed several libraries of small molecules and macrocycles that could facilitate the discovery of novel valuable lead compounds using either target-directed or target-unbiased screening approaches. Specific designs include a-helix mimetics, glycomimetic, diverse synthetic macrocyles, and tri/tetra-substituted scaffolds.
SL#061 Antimalarial Agents-1	80 compounds Pre-Plated Set Release: 2017	Several interesting novel scaffolds have been identified using this HTS platform providing promising starting points for medchem optimization. More specifically, derivatives of benzothiophene-2-carboxylic acids have been investigated to provide several important SAR insights for further development. Similarity searches in Asinex compound collection have revealed several benzothiophene-2-carboxamide core-containing molecules that could be used for additional exploration of this promising chemoptype.
SL#069 Interferon inducers	80 compounds Pre-Plated Set Release: 2017	The first small molecule interferon (INF) inducers were discovered several decades ago as a result of an extensive search of antiviral agents. The mode of action of many INF inducers remains unknown, while many researchers connect interferon induction with the function of the ER-resident protein STING. Small molecules 10-carboxymethyl-9-acridanone (CMA), (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)-acetic acid (DMXAA), and G10 were shown to trigger INF induction in a STING-dependent manner. 80 close structural analogs of CMA, DMXAA, and G10 have been included in this library.
SL#070 HIV TAR RNA small molecule binders	80 compounds Pre-Plated Set Release: 2017	Using a combination of biophysical and cell-based experiments a group from the National Cancer Institute has identified several derivatives of thienopyridine and phenothiazine that bind to HIV transactivation response (TAR) with high potency and selectivity. Close analogs of the reported hits might be interesting for further SAR exploration and elucidation of specific RNA-binding elements.

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α-Helix Mimetics	6867 compounds For cherry-picking Update: 2020-07	It is well known that α-helix mimetics are biologically active in a number of therapeutically significant protein-protein interactions (PPIs). The file contains all available α-Helix mimetics selected from our Signature & BioDesign Libraries.
SL#030 α-Helix mimetics	80 compounds Pre-Plated Set Update: 2016	Using extensive computer modeling supported by in vitro experiments, ASINEX has created a number of structurally sophisticated, novel molecules based on the tetrahydropyrane scaffold that work as effective epitope mimetics of more than 20 various helical protein interfaces (e.g. ATG3/ATG12, Bcl-2, Aquaporin 2, Protein S100-A9).
SL#032 Macrocyclic BH3 mimetics	80 compounds Pre-Plated Set Update: 2016	Extensive in vitro screening of the Asinex Macrocyclic collection has revealed a series of molecules showing a μM range of activity against anti-apototic proteins Bcl-2 and Mcl-1. In silico modeling studies suggest that some active macrocycles can adopt a-helix-mimetic conformations that effectively mimic the BH3-epitope of pro-apoptotic peptides (e.g. Bak, Bax).

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Nucleoside Mimetics	3118 compounds For cherry-picking Update: 2020-07	ASINEX has developed a number of stereo- and enantio-selective methods for the synthesis of nucleoside-like core intermediates (e. g. mimics of adenosine). These unique intermediates have been extensively decorated by various long chain amines, acids and amino acids.
Dinucleoside Mimetics for RNA	842 compounds For cherry-picking Update: 2020-10	Systematic analysis of published small molecules with declared RNA activity has revealed several prominent structural elements that can be used as design templates for the creation of novel chemical libraries for RNA drug discovery. In particular, a combination of aromatic heterocyclic rings such as nucleobases or bioisosteric analogs with a saturated linear or ring component connected via a carbon-carbon bond are very common motifs among RNA-bound ligands with favorable drug-like properties. This observation confirms earlier published data suggesting that molecules having a favorable carbon bond saturation (defined by Fsp3) represent “biologically relevant chemical space” . In the case of RNA ligands, the right balance of aromaticity and saturation embedded in the RNA-compatible molecular framework may enhance binding probability. ASINEX have identified several such advantageous combinations.
Nucleoside-mimetics Pre-Plated Set	3826 compounds Pre-Plated Set Amount: 0.01-2.0 mg Update: 2018-04	ASINEX ‘s Nucleoside-mimetics Pre-plated Sets are designed to provide popular screening libraries in a convenient and cost-effective manner.
SL#010, 052, 098 Purine-based Nucleosides	80 compounds x 3 Pre-Plated Set Release: 2016-2018	Compounds targeting the SAM/SAH site of these enzymes offer great potential, yet very few such molecules are currently described in literature or commercially available in compound collections. To address this market need, ASINEX has used a modular approach to synthesize a library of purine-based nucleosides. The main challenge was to develop stereo- and enantio-selective methods for the synthesis of nucleotide-like cores which both mimic adenosine and are metabolically stable
SL#099 Pyrimidine-based Nucleosides	80 compounds Pre-Plated Set Release: 2018	Nucleoside mimetics are the class of small molecule drugs with antitumor, antiviral, and antibacterial activity. Alterations in the base or sugar moieties can lead to significant changes in pharmacokinetic and pharmacodynamic properties of these molecules. Many convenient synthetic methods have been developed for modification of naturally occurring nucleosides, but synthetic analogs would require non-conventional approaches involving stereo- and enantio-selective reactions. In this library, a variety of pyrimidine nucleobases was linked to a number of synthetic glycomimetic cores, followed by modifications of the terminal amino group. The resulting nucleoside mimetic molecules do not have a glycosidic linkage which may be beneficial for optimizing metabolic properties.

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Glycomimetics	4292 compounds For cherry-picking Update: 2020-07	The file contains all available Glycomimetics selected from our Signature & BioDesign Libraries.
Macrocyclic Glycomimetics	1412 compounds For cherry-picking Update: 2020-07	Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites.
SL#006, 007, 017, 028 Glycomimetics	80 compounds x 4 Pre-Plated Set Release: 2016	ASINEX has overcome these obstacles by creating a glycomimetic library that ensures the bioactive function of carbohydrates while addressing the drawbacks of carbohydrates, such as their low activity and poor drug-like properties.
SL#038 Glycomimetics/Immunology	80 compounds Pre-Plated Set Release: 2016	ASINEX has employed unique synthetic methods to create a library of synthetic glycomimetics where the carbohydrate ring is replaced by pyrrolidine.
SL#008, 016, 036, 039, 100 Macrocyclic Glycomimetics	80 compounds x 5 Pre-Plated Set Release: 2016-2018	Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites
SL#055, 056 Arabinose Glycomimetics	80 compounds x 2 Pre-Plated Set Release: 2016	ASINEX has created a library of glycomimetic derivatives based on D-(-)-Arabinose. The presence of amine in the resulting scaffold allows a broad variation of substituents while retaining the stereochemical configuration of the cyclic amino polyol scaffold.
SL#057, 058 Carbocyclic Glycomimetics	80 compounds x 2 Pre-Plated Set Release: 2016	ASINEX has developed an efficient synthetic strategy to create five and six-membered carbocylic glycomimetic scaffolds with strategically orientated peripheral substituents.

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Aichi Japan

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