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GPCR


Product Name: Format/Size Descriptions Download
GPCR Library 8532 compounds
For cherry-picking
Update: 2020-07
The file contains all available GPCR compounds selected from our Signature & BioDesign Libraries.
Lipid GPCR Library 2344 compounds
Update: 2020-07
The file contains ALL Lipid GPCR compounds for cherry-picking.
Peptide GPCR Library
(Macrocycles)
6285 compounds
Release: 2020-07
The file contains ALL Peptidergic GPCR macrocycles for cherry-picking.
SL#014
Peptide GPCRs,
SST4R agonists
80 compounds
Pre-Plated Set
Release: 2016
ASINEX's GPCR screening platform including an SST4 binding assay, SST4 GTPγS assay, and SST4 cell functional assays, has identified several potent modulators of SST4R.
SL#078
Sympathomimetics
chemical probes
80 compounds
Pre-Plated Set
Release: 2017
Asinex has developed several analogs of Propranolol - first clinically successful sympathomimetic, containing the characteristic 3-amino-2-hydroxypropanol fragment.
SL#088
Free Fatty Acid Receptor
(FFAR) Regulators
80 compounds
Pre-Plated Set
Release: 2018
Known small molecule agonists of FFA receptors share some common pharmacophoric features, such as a carboxylic acid moiety attached directly or via an aliphatic tail to an aromatic core. A pharmacophore search through ASINEX’s compound collection identified several hits that can be explored for FFA research and drug discovery.
SL#089
Dopamine receptor type 2
(DRD2) inhibitors
80 compounds
Pre-Plated Set
Release: 2018
Several recent studies demonstrated that dopamine receptors D2 are associated with tumorigenesis. Some antipsychotic drugs showed anti neoplastic effects on human cancers as adjuvants enhancing the effi¬cacy of anticancer therapy in breast and colon cancer cell lines. A pharmacophore search through ASINEX’s compound collection identified several molecules that can be explored for GPCR research and anticancer drug discovery.
SL#090
κ-Opioid receptor
(KOR) agonists
80 compounds
Pre-Plated Set
Release: 2018
Recent report shows a novel chemical series of KOR agonists based on a triazole scaffold. The lead compound Triazole 1.1 was tested in vivo and demonstrated a preservation of the analgesic properties with no signs of the sedating or dysphoric effects of typical KOR agonists.
Analogs of the reported triazole lead series were included into this library.
Contact
Global

Ludmila Sadovenko

lsadovenko@asinex.com
North America

Mark Parisi

mparisi@asinex.com

Toll Free: +1 877 ASINEX1

Tel: +1 336 721 1617

Fax: +1 336 721 1618

N.Chestnut St., Ste.104

Winston-Salem, NC 27101

USA

Europe

Galina Afanasyeva

gafanasyeva@asinex.com

Tel: +31 (0) 203416183

Klaprozenweg 75C, 1033NN

Amsterdam, The Netherlands

Japan

Shingo Ota

sota@asinex.com

Tel: 080-3401-9097

30-2 Higashihazu, Nishio,

Aichi Japan

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