Metal Chelate Library |
1794 compounds Release: 2021-04 |
The file contains ALL Metal Chelate compounds for cherry-picking. |
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Steroid Mimetics |
1456 compounds Release: 2020-07 |
The file contains ALL Steroid mimetics for cherry-picking. |
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Terpenoid Mimetics
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4278 compounds Release: 2020-07 |
ASINEX generates a unique library of skeletally diverse (saturated fused-, spiro-
systems) highly oxygen rich molecules. The synthetic strategy is based on biomimetic
transformations of natural terpenoid products, such as NOPOL, NEROL and GERANIOL,
into novel polyether derivatives. These cyclic molecules contain several versatile
functionalities (OH, NH, COOH) which are amenable to further medicinal chemistry
exploration.
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SL#059, 060 Oxo-SpiroPyrrolidines |
80 compounds x 2 Pre-Plated Set Release: 2016 |
Asinex has developed a versatile synthetic approach to skeletally diverse novel
spiro scaffolds that are based on a rare combination of O- and N-containing cycles
with additional synthetic handles. This allows the introduction of various
peripheral fragments which, in turn, create derivatives with a very attractive
physico-chemical profile.
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SL#093 Gem-diMe-Heterocycles |
80 compounds x 1 Pre-Plated Set Release: 2018 |
The gem-dimethyl moiety is one of the most commonly occurring structural elements
found in many pharmacologically relevant natural products (e.g. taxanes, statins).
This element is also successfully used by medicinal chemists for improving potency
and pharmacokinetic properties of drug candidates. Three-dimensional character of
this element in combination with adjacent O, N heteroatoms translates into a broad
diversity of molecular shapes and can facilitate the formation of a bioactive
conformation upon binding to a target protein. Enrichment of the screening
library with small molecules containing this important pharmacophore can contribute
to the discovery of potent hits against multiple targets.
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SL#094 4-anilinopiperidines |
80 compounds x 1 Pre-Plated Set Release: 2018 |
4-Anilinopiperidine is a prominent pharmacophoric element recognizable among
synthetic opioid analgesics. Structural variations around the 4-anilinopiperidine
core greatly determine the structure–activity relationship properties such us target
receptor selectivity, pharmacokinetic and safety profiles. The main structural
changes may involve replacement of piperidine ring, replacement of phenyl ring and
introduction of an additional substituent at the fourth position of piperidine
ring. Annulation of an additional saturated ring to the piperidine ring increases
molecular rigidity leading to a series of novel
octahydro‐1H‐pyrrolo[3,2‐c]pyridines. These derivatives can be potentially
interesting for pharmaceutical research of novel analgesics and related
applications.
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SL#095 3-anilinopiperidines |
80 compounds x 1 Pre-Plated Set Release: 2018 |
3-Anilinopiperidine - a structural isomer of 4-anilinopiperidine which in turn
represent a recognizable pharmacophore among synthetic opioid analgesics. Structural
variations around the anilinopiperidine core greatly determine the
structure–activity relationship properties. Annulated bicyclic molecules,
incorporating 3-anilinopiperidine fragment, can be potentially interesting for
pharmaceutical research and development.
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SL#096 Spiro pyrrolidines |
80 compounds x 1 Pre-Plated Set Release: 2018 |
3-Anilinopiperidine - a structural isomer of 4-anilinopiperidine which in turn
represent a recognizable pharmacophore among synthetic opioid analgesics. Structural
variations around the anilinopiperidine core greatly determine the
structure–activity relationship properties. Annulated bicyclic molecules,
incorporating 3-anilinopiperidine fragment, can be potentially interesting for
pharmaceutical research and development.
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SL#097 Medium-sized (8 atom) Heterocycles |
80 compounds x 1 Pre-Plated Set Release: 2018 |
Medium-sized rings are very interesting class of molecular frameworks that can be
found in many bioactive natural products and clinical candidates. Synthetic
medium-sized scaffolds are underrepresented in commercial screening collections due
to limited arsenal of convenient methods of their synthesis. Several efficient
synthetic methods for the preparation of medium-sized rings have been reported:
lactonization, lactamization, and ring-closing metathesis. However, conventional
ring closing methods have their significant limitations. Rearrangements and ring
expansion reactions can introduce additional scaffold diversity and are compatible
with many functional groups. A Cu-catalyzed coupling of β-lactam substrates with
aryl bromides is a simple and convenient method for the preparation of 8- and
9-membered ring systems that constitute this library.
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