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CNS


Product Name: Format/Size Descriptions Download
CNS Library 120883 compounds
For cherry-picking
Update: 2020-07
The file contains all available CNS biased compounds selected from our Signature & BioDesign Libraries.
CNS Macrocycles 1122 compounds
For cherry-picking
Update: 2020-07
CNS Diversity
Pre-Plated Set
6055 compounds
Pre-Plated Set
Amount: 0.01-2.0mg
Release: 2020-07
ASINEX has selected CNS-like molecules with high diversity:
CNS-MPO > 4
CNS-MPO.v2 > 4
CNS-TEMPO < 4
SL#044
CNS set (PAMPA BBB)
80 compounds
Pre-Plated Set
Release: 2016
In-vitro screening of ASINEX’s BioDesign collection has revealed a number of CNS-like molecules with high PAMPA-BBB permeability properties (Pe >10 x 10-6cm/s). A diversity-selection of the most permeable compounds has been used as the basis for this library which can be further expanded through available analogs.
SL#048
ApoE activators (agonist)
80 compounds
Pre-Plated Set
Release: 2016
A library of 15000 natural product like compounds has been screened in vitro in CCF-STTG (human astrocytoma) cells against ApoE secretion using an ELISA assay. A number of primary hits have been further optimized to provide compounds with ApoE secretion agonistic activity in the range of 0.6-15 µM.
SL#073
CNS kinase -
DLK (MAP3K12)
80 compounds
Pre-Plated Set
Release: 2017
80 analogs of the reported hits have been included in this library.
SL#076
OxyTerpenoids for CNS
80 compounds
Pre-Plated Set
Release: 2017
ASINEX has developed a synthetic toolbox which has enabled us to generate a unique library of skeletally diverse terpenoid-like molecules.
These molecules are particularly interesting for CNS-related research due to favorable CNS-likeness properties: CNS-MPO score >4 and high PAMPA-BBB.
SL#077
Morpholines for CNS
80 compounds
Pre-Plated Set
Release: 2017
Asinex has developed several novel lead-like morpholine-containing small molecules, that predictably demonstrate favorable CNS-like properties (CNSMPO >4).
SL#078
Sympathomimetics
chemical probes
80 compounds
Pre-Plated Set
Release: 2017
Asinex has developed several analogs of Propranolol - first clinically successful sympathomimetic, containing the characteristic 3-amino-2-hydroxypropanol fragment.
SL#079
Piperidines for CNS-1
80 compounds
Pre-Plated Set
Release: 2017
Asinex have created a series of novel piperidine containing molecules, that have favorable CNS-like physico-chemical properties making these compounds an interesting screening set for CNS-directed research.
SL#080
Analgesic for CNS
80 compounds
Pre-Plated Set
Release: 2017
Asinex has created several novel 3-substituted 2-benzylpiperidine derivatives that represent an interesting chemotype for studying opiod receptor signaling.
SL#091
Fatty Acid Amide Hydrolase
(FAAH) inhibitors
80 compounds
Pre-Plated Set
Release: 2018
Synthetic inhibitors of FAAH have been explored as promising candidates for the treatment of several disease conditions including pain, inflammation and mood disorders. Several promising chemical series such as carbamates and arylureas, have been optimized and moved into clinical trials. Analogs of the reported clinical candidates were included into this library.
Contact
Global

Ludmila Sadovenko

lsadovenko@asinex.com
North America

Mark Parisi

mparisi@asinex.com

Toll Free: +1 877 ASINEX1

Tel: +1 336 721 1617

Fax: +1 336 721 1618

N.Chestnut St., Ste.104

Winston-Salem, NC 27101

USA

Europe

Galina Afanasyeva

gafanasyeva@asinex.com

Tel: +31 (0) 203416183

Klaprozenweg 75C, 1033NN

Amsterdam, The Netherlands

Japan

Shingo Ota

sota@asinex.com

Tel: 080-3401-9097

30-2 Higashihazu, Nishio,

Aichi Japan

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