| CNS Library |
120883 compounds
For cherry-picking
Update: 2020-07
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The file contains all available CNS biased compounds selected from our Signature &
BioDesign Libraries.
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| CNS Macrocycles |
1122 compounds
For cherry-picking
Update: 2020-07
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CNS Diversity
Pre-Plated Set |
6055 compounds
Pre-Plated Set
Amount: 0.01-2.0mg
Release: 2020-07 |
ASINEX has selected CNS-like molecules with high diversity:
CNS-MPO >
4
CNS-MPO.v2 > 4
CNS-TEMPO < 4
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SL#044
CNS set (PAMPA BBB) |
80 compounds
Pre-Plated Set
Release: 2016 |
In-vitro screening of ASINEX’s BioDesign collection has revealed a number of
CNS-like molecules with high PAMPA-BBB permeability properties (Pe >10 x
10-6cm/s). A diversity-selection of the most permeable compounds has been used as
the basis for this library which can be further expanded through available
analogs.
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SL#048
ApoE activators (agonist) |
80 compounds
Pre-Plated Set
Release: 2016 |
A library of 15000 natural product like compounds has been screened in vitro in
CCF-STTG (human astrocytoma) cells against ApoE secretion using an ELISA assay. A
number of primary hits have been further optimized to provide compounds with ApoE
secretion agonistic activity in the range of 0.6-15 µM.
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SL#073
CNS kinase -
DLK (MAP3K12) |
80 compounds
Pre-Plated Set
Release: 2017 |
80 analogs of the reported hits have been included in this library.
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SL#076
OxyTerpenoids for CNS |
80 compounds
Pre-Plated Set
Release: 2017 |
ASINEX has developed a synthetic toolbox which has enabled us to generate a unique
library of skeletally diverse terpenoid-like molecules.
These molecules are
particularly interesting for CNS-related research due to favorable CNS-likeness
properties: CNS-MPO score >4 and high PAMPA-BBB.
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SL#077
Morpholines for CNS |
80 compounds
Pre-Plated Set
Release: 2017 |
Asinex has developed several novel lead-like morpholine-containing small molecules,
that predictably demonstrate favorable CNS-like properties (CNSMPO >4).
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SL#078
Sympathomimetics
chemical probes |
80 compounds
Pre-Plated Set
Release: 2017 |
Asinex has developed several analogs of Propranolol - first clinically successful
sympathomimetic, containing the characteristic 3-amino-2-hydroxypropanol
fragment.
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SL#079
Piperidines for CNS-1 |
80 compounds
Pre-Plated Set
Release: 2017 |
Asinex have created a series of novel piperidine containing molecules, that have
favorable CNS-like physico-chemical properties making these compounds an interesting
screening set for CNS-directed research.
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SL#080
Analgesic for CNS |
80 compounds
Pre-Plated Set
Release: 2017 |
Asinex has created several novel 3-substituted 2-benzylpiperidine derivatives that
represent an interesting chemotype for studying opiod receptor
signaling.
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SL#091
Fatty Acid Amide Hydrolase
(FAAH) inhibitors |
80 compounds
Pre-Plated Set
Release: 2018 |
Synthetic inhibitors of FAAH have been explored as promising candidates for the
treatment of several disease conditions including pain, inflammation and mood
disorders. Several promising chemical series such as carbamates and arylureas, have
been optimized and moved into clinical trials. Analogs of the reported clinical
candidates were included into this library.
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