| Ion-Channel Library |
8559 compounds
For cherry-picking
Update: 2025-01 |
The file contains all available Ion-Channel compounds selected from our Signature &
BioDesign Libraries. For more information, please download >>> |
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SL#005, 051
Ion Channel Modulators
Nav1.8 |
80 compounds x 2
Pre-Plated Set
Update: 2025-01 |
Based on the analysis of several known NaV1.8-blockers ASINEX has developed a
pharmacophore model which has been used to carry out an exhaustive search on a
20000+ set of natural product-like compounds. The highest scoring compounds were
screened in vitro in the human Nav1.8/β3 sodium channel cell line.
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SL#092
Ion Channel
Modulators Nav1.7 |
80 compounds
Pre-Plated Set
Update: 2025-01 |
A recent study reported a series of pyrrolopyrimidine derivatives as highly potent
and state-dependent inhibitors of Nav1.7. Analogs of the reported chemotypes were
included into this library.
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SL#041
Voltage-gated
sodium channels |
80 compounds
Pre-Plated Set
Update: 2025-01 |
ASINEX has identified a number of ion-channel modulators against undisclosed
voltage-gated ion channels. This library is useful for ion channel research and drug
discovery.
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SL#064
TMEM16A
Channel Modulators |
80 compounds
Pre-Plated Set
Update: 2025-01 |
Transmembrane protein 16A (TMEM16A) inhibitors have been proposed for treatment of
disorders of epithelial fluid and mucus secretion, hypertension, asthma, and
possibly cancer. A recent study revealed that a series of
2-acylaminocycloalkylthiophene-3-carboxylic acid arylamides can inhibit TMEM16A at
low nM concentrations. 80 close analogs of the most potent inhibitor 10bm were
included into this library.
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SL#081
Aankyrin-like receptor family
(TRPA1) Agonists |
80 compounds
Pre-Plated Set
Update: 2025-01 |
A recent study reported several electrophilic compounds that covalently modify
reactive cysteine residues revealing important insights about the key SH groups
involved in TRPA1 activation. Analogs of the reported molecules were included into
this library.
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SL#084
Inhibitors of TRPC3/6/7 |
80 compounds
Pre-Plated Set
Update: 2025-01 |
A series of pyrazolopyrimidine derivatives has been recently discovered as potent
agonists of TRPC3/6/7 channels. Structural analogs of the reported ion channel
modulators were included into this library.
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