
Macrocyclic Compound Libraries
Medicinal chemists have long considered compounds with medium- and large-sized rings to be a distinct class of molecules, not only because of their interesting biological properties but also due to the specificfeatures of their synthesis. ASINEX has extensively researched the development of the most effective synthetic methods leading to macrocyclic entities and their corresponding pharmacological properties with a particular focus on solubility and cellular permeability. Currently, Asinex is the leading source of macrocyclic screening compounds of unparalleled diversity which covers both peptide-like and non-peptidicchemotypes. Our macrocyclic library is comprised of 200+ scaffolds and this number is growing, making our library the largest commercial screening collection of scaffold-based macrocycles. Macrocycles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. Their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds facilitates a balance between aqueous solubility and cellular permeability. More than 4000 of our macrocycles have been tested for aqueous solubility and PAMPA permeability.This valuable dataset was used to build up an ML-based computational model to predict the permeability of novel macrocycles based on their 2D and 3D descriptors. Please visit our online catalog for available macrocyclic compounds or contact our customer support team for any additional information about our macrocycle-directed platforms.
Ludmila Sadovenko
lsadovenko@asinex.comTel: +31 (0) 203416183
Klaprozenweg 75C, 1033NN
Amsterdam, The Netherlands
Mark Parisi
mparisi@asinex.comToll Free: +1 877 ASINEX1
Tel: +1 336 721 1617
Fax: +1 336 721 1618
N.Chestnut St., Ste.104
Winston-Salem, NC 27101
USA