Covalent Fragments

Covalent fragments are increasingly popular chemical probes for validation and characterization of target proteins as well as generating valuable starting points for the design of effective inhibitors and degraders. The combination of the appropriate electrophilic warhead targeting specific amino-acid residues (Cys, Lys, Thr, Tyr, Ser, His) and a relatively simple fragment-like moiety results in valuable tool compounds that can be screened in various widely adopted HTS settings. Our Covalent Fragments are “Rule of 3” (Ro3)-compliant and available for purchase either as a whole collection or by picking and choosing individual items.