E3 Ligase Ligands

ASINEX has created a library of E3 ligase ligands to facilitate your research in the field of targeted protein degradation (PROTACs). The proposed molecules represent the diversity of the most popular and drug-like Cereblon (CRBN)-binding building blocks that are commonly used in the design of successful protein degradation bifunctional molecules. These CRBN-binding cores and their heterocyclic analogs can be connected with bifunctional extension linkers via C-N, C-O and C-C bonds which provide the opportunity to explore novel IP-enabling combinations. All E3 ligand compounds conform to the highest quality standards for HPLC purity and structural LC-MS and 1H NMR characterization.