E3-Linker Conjugates

ASINEX has created a library of diverseE3-Linker Conjugates to facilitate your research in the field of targeted protein degradation, focusing on PROTACswith improved cell permeability and solubility. The conjugateswere created by coupling E3 Ligase binding fragments with a selection of bifunctional linkers. In creating this library, we favored molecules that are underrepresented among other publicly available screening collections while maintaining a balance of structural diversity and complexity.
The terminal functionalityof the resulting E3-Linker conjugates is represented by 1) primary&secondaryamines, 2) carboxylic acids, 3) alcohols, 4) epoxides and 5) alkynes which allow convenient coupling with your target ligand. We have put great effort into the optimization of synthetic protocols and purification procedures to deliver high quality products with robust scalability potential.
All catalogE3-Linker Conjugatesconform to the highest quality standards for purity and structuralcharacterizationas confirmed by both LC-MS and 1H NMR data.