en

Linkers

The properties of each linker (length, composition of atoms and rigidity) may significantly impact the spatial orientation and alignment of the two functional elements of PROTACs. We have assembled a collection of 100+ linkers which include the most popular flexible polyethylene glycol (PEG) chains as well as more rigid heterocycle-containing linkers (piperidine-based and piperazine-based). The terminal functionality of our linkers represents a diverse selection of functional groups: diamines, amino acids, amino alcohols, amino alkynes, and amino epoxides.
The potential therapeutic application of bifunctional molecules goes far beyond protein degraders (e.g. selective RNA degradation with ribonuclease targeting chimeras RIBOTAC or protein stabilization with DUPTAC) making the connection of two functional ligands with a proper linker a versatile approach for the design of new therapeutic modalities with superior properties. All our linker building blocks conform to the highest quality standards for HPLC purity and structural LC-MS and 1H NMR characterization.



BAS 0773136
BAS 0773136
50 mg
$80
add
BAS 10150520
BAS 10150520
50 mg
$50
add
BAS 21098498
BAS 21098498
50 mg
$50
add
BFE 30011920
BFE 30011920
$80
add
LAS 26567784
LAS 26567784
50 mg
$50
add
LAS 99763249
LAS 99763249
50 mg
$50
add
LAS 99763818
LAS 99763818
50 mg
$80
add
LAS 99765183
LAS 99765183
50 mg
$50
add
LAS 99891440
LAS 99891440
50 mg
$80
add
LAS 99896253
LAS 99896253
50 mg
$200
add
LAS 99896256
LAS 99896256
50 mg
$250
add
LAS 99899572
LAS 99899572
50 mg
$80
add
Contact
Global

Ludmila Sadovenko

lsadovenko@asinex.com
North America

Mark Parisi

mparisi@asinex.com

Toll Free: +1 877 ASINEX1

Tel: +1 336 721 1617

Fax: +1 336 721 1618

N.Chestnut St., Ste.104

Winston-Salem, NC 27101

USA

Europe

Galina Afanasyeva

gafanasyeva@asinex.com

Tel: +31 (0) 203416183

Klaprozenweg 75C, 1033NN

Amsterdam, The Netherlands

Japan

Shingo Ota

sota@asinex.com

Tel: 080-3401-9097

30-2 Higashihazu, Nishio,

Aichi Japan

Cart
Your cart is empty
Order
$
0
Checkout
Thanks for your order
We will contact you shortly